Accutane is the trade name for Isotretinoin which is a medication used for the treatment of severe acne. It was first developed in the treatment of harsh cancer as a chemotherapy medication, but it showed that it could be used to kill off rapidly dying skin cells. It was marketed under several trade names that included Roaccutane, Accutane, Amnesteem, Claravis, Clarus, Decutan, Isotane, Izotek, Oratane, ISOTRE, Sotret, Isotrex, and Isotrexin. All these medications are just brand names for the same thing. It was developed in the 1930s, and it showed that sebum production was greatly reduced when it was given at the expense of extremely dry, brittle, rigid hair. Patients often tend to become much healthier when they start ingesting this substance because their diets often do not include enough vitamin A. Vitamin A can reduce sebum production so it is a good thing to take for acne because overactive or improperly clogged sebum glands are indicated in acne. This drug should be taken after a high fat meal because it is absorbed best in the presence of other fats because it is highly lipophilic. It is only used after other acne fail to present any real results because this is a very serious medication. This drug is indicated in the treatment of systemic, severe, and intense acne vulgaris. The drug may only be prescribed under the attendant care of a dermatologist in most countries. Dosages are not standardized. They are given across a range of severity profiles for the condition. Most all patients receive clearing of the skin at high dosages, but adverse effects at very high dosages can include hepatitis and psychosis along wih cataracts and myalgia. Some people prefer it is better to let nature take its course and let acne heal naturally, but for people that are adults who have acne that hasnít disappeared yet, it is perhaps best to take Accutane.